Publications by authors named "M T McCulloch"

Introduction: The lack of peritoneal dialysis (PD) catheters designed explicitly for neonates creates significant challenges in the provision of neonatal peritoneal dialysis. High resource settings can circumvent this limitation by resorting to alternative extracorporeal dialysis methods. However, low resource settings (LRS), PD remains the preferred dialysis modality, and the use of off-label catheters for PD results in complications such as omental wrapping and occlusion.

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The coronavirus disease 2019 (COVID-19) pandemic, instigated by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has profoundly impacted healthcare infrastructures around the globe. While children are usually asymptomatic or have mild symptoms, children with pre-existing kidney conditions require specialized attention. This pivotal report, championed by the International Pediatric Nephrology Association (IPNA), delivers precise and actionable recommendations tailored for pediatric patients with kidney ailments in this pandemic landscape.

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Background: Blood group incompatibility previously represented an obstacle to living related donor (LRD) options; desensitization modalities have expanded LRD options. ABO-incompatible kidney transplants have been successful in adults and pediatric liver transplants, but to date not yet in pediatric kidney transplants in South Africa.

Case Report: Patient X is a 5 year old male with end-stage kidney failure due to Posterior Urethral Valves, requiring peritoneal dialysis pre-transplant.

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Background: Pediatric organ transplantation is the primary treatment for end-organ failure. Improving medication adherence and healthcare compliance can decrease healthcare burdens, graft rejection, morbidity, and mortality. Adolescents commonly struggle with non-adherence, necessitating a smooth transition to adult care.

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Article Synopsis
  • Bicuspid aortic valve is the most common congenital heart defect and can lead to lifestyle restrictions that increase obesity risk; this study explores the impact of obesity on aortic dimensions and valve function in affected youth.
  • A retrospective analysis was conducted on 251 individuals aged 5 to 25 with bicuspid aortic valve, categorizing them as either healthy weight or overweight/obese, and evaluating their aortic measurements via echocardiograms.
  • Results showed that overweight/obese patients had larger aortic valve annulus and sinotubular junction sizes, and experienced worse aortic valve function compared to their healthy weight counterparts, indicating a risk of more severe aortic valve stenosis in the heavier group.
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