Publications by authors named "M T Kalcioglu"
Purpose: Safety and efficacy of SENS-401, a serotonin type 3 (5-HT) receptor antagonist and calcineurin inhibitor, in patients with acute sudden sensorineural hearing loss (SSNHL).
Methods: Multicentre randomized, double blind, placebo-controlled trial enrolled adult subjects with sudden sensorineural hearing loss (SSNHL) or unilateral/bilateral acute acoustic trauma leading to SSNHL within 96 h of disease onset. Subjects were randomly assigned to one of the three oral dose groups: 29 mg, 43.
Although advanced technologies and surgical procedures are used, cholesteatoma is a disease with the possibility of recurrence. The aim of this study was to determine the long-term effect of sodium 2-mercaptoethane sulfonate (MESNA) on cholesteatoma surgery. Patients who underwent cholesteatoma surgery between January 2009 and July 2014 by the same surgeon were divided into 2 groups: those where MESNA was used and those where it was not.
View Article and Find Full Text PDFObjectives: The aim of this study was to evaluate vestibulo-ocular reflex (VOR) of individuals over 60 years of age who have not been diagnosed with a specific vestibular pathology.
Methods: Bilateral six-semicircular canal video head impulse test (vHIT), Dizziness Handicap Inventory and European Evaluation of Vertigo scales were applied to participants.
Results: In total, 103 participants were included in the study (75 male, 28 female), and the mean age was 69.
Article Synopsis
- Hearing loss (HL) can be caused by variations in over 200 genes, but many families still don't receive a clear genetic diagnosis despite extensive testing.
- In a study involving families with severe to profound, non-syndromic bilateral sensorineural HL, researchers used advanced genetic sequencing techniques to uncover the complexity of multiple gene variants contributing to HL in family members.
- One novel finding included a variant in the TOGARAM2 gene, suggesting it could be linked to autosomal recessive non-syndromic HL, highlighting the importance of analyzing each affected individual to identify both known and potential new HL-related genes.