Oxidative stress, caused by the accumulation of reactive oxygen species (ROS), is a pathological factor in several incurable neurodegenerative conditions as well as in stroke. However, our knowledge of the genetic elements that can be manipulated to protect neurons from oxidative stress-induced cell death is still very limited. Here, using Caenorhabditis elegans as a model system, combined with the optogenetic tool KillerRed to spatially and temporally control ROS generation, we identify a previously uncharacterized gene, oxidative stress protective 1 (osp-1), that protects C.
View Article and Find Full Text PDFA SUMMARY OF WHAT IS NEW OR DIFFERENT? This chapter focuses on insulin pump therapy, with a greater emphasis on glucose-responsive integrated technology that is feasible with the use of automated insulin delivery (AID) systems. The chapter also includes connected insulin pens and insulin pump therapy without AID functionality. As behavioral, psychosocial, and educational considerations of insulin delivery devices are a central part of diabetes self-management and use of insulin delivery devices, these topics are also addressed.
View Article and Find Full Text PDFLong-term follow-up for individuals with hypospadias remains a critical area of need, yet evidence-based guidelines for such follow-up are lacking, and the role of involvement of relevant experts is not yet established. Using our hypospadias-specific health-related quality of life conceptual framework and a subsequent qualitative study of prepubertal males and parents of males with hypospadias, we identified potential priorities for long-term follow-up of youth with hypospadias. Using thematic codes from our patient and parent interviews, we searched PubMed for relevant articles and identified the specialties represented by all the authors of these articles.
View Article and Find Full Text PDF