Publications by authors named "M T Handoko"
Background: Ketogenic diet is an effective therapy for patients with medically refractory epilepsy. It is generally well tolerated, with the most common side effects being gastrointestinal. Hepatic toxicity has been described as an uncommon side effect of ketogenic diet, usually with long-term use.
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- - The study examines the relationship between kidney function and echocardiography findings related to left ventricular diastolic dysfunction (LVDD) in patients from a university hospital, categorizing them by levels of kidney function based on estimated glomerular filtration rate (eGFR).
- - Among 4,022 patients, those with increasingly decreased kidney function showed higher odds of having abnormal echocardiographic parameters, including the E/e' ratio and left ventricular mass index (LVMI), indicating a clear connection between deteriorating kidney health and worsening cardiac function.
- - The findings reveal that even mildly decreased kidney function is associated with signs of LVDD, suggesting that as kidney function declines, the risk of echocardiographic abnormalities in
Guideline-directed medical therapy (GDMT) has clear benefits on morbidity and mortality in patients with heart failure; however, GDMT use remains low. In the multicenter, open-label, investigator-initiated ADMINISTER trial, patients (n = 150) diagnosed with heart failure and reduced ejection fraction (HFrEF) were randomized (1:1) to receive usual care or a strategy using digital consults (DCs). DCs contained (1) digital data sharing from patient to clinician (pharmacotherapy use, home-measured vital signs and Kansas City Cardiomyopathy Questionnaires); (2) patient education via a text-based e-learning; and (3) guideline recommendations to all treating clinicians.
View Article and Find Full Text PDFHeart failure with preserved ejection fraction (HFpEF) is under-recognized in clinical practice. Although a previously developed risk score, termed HFPEF, can be used to estimate HFpEF probability, this score requires imaging data, which is often unavailable. Here we sought to develop an HFpEF screening model that is based exclusively on clinical variables and that can guide the need for echocardiography and further testing.
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