Cellular accumulation and activity of quinolones in ciprofloxacin-resistant J774 macrophages.

Ciprofloxacin is the substrate for a multidrug resistance-related protein (MRP)-like multidrug transporter in J774 mouse macrophages, which also modestly affects levofloxacin but only marginally affects garenoxacin and moxifloxacin (J.-M. Michot et al.

Severe idiopathic congenital aplastic anemia: role of hematopoietic growth factors.

A baby boy with constitutional aplastic anemia refractory to treatment with hematopoietic growth factors underwent BMT from an unrelated HLA-compatible donor. The BM failed to engraft but the combination of a conditioning regimen, immunosuppression and hematopoietic growth factors resulted in a recovery of the patient's own BM and a good outcome.

Plasma infusion as treatment for 33 children with haemolytic uraemic syndrome: a good therapy?

Between May 87 and December 91, 33 children aged from 2 months to 13 9/12 years were admitted for haemolytic uraemic syndrome (HUS). Treatment consisted of daily fresh-frozen plasma infusion (20 ml/kg/day) during 14 days. On admission, 20 patients (61%) had an oligoanuria: 18 underwent a peritoneal dialysis and 2 an haemodialysis with a median duration of dialysis of 14 days.

Psychological sequelae to carbon monoxide intoxication in the child.

Twenty children from 25 months to 15 years old at the time of carbon monoxide intoxication have been studied in a short-term follow-up, and 14 children in a long-term follow-up, as far as their psychological and cognitive faculties are concerned. The quality of recovery is a function of the severeness of the intoxication, but the intellectual level of the children, and primarily their age at the time of the intoxication, also play a major role.