E. Coli cytotoxic necrotizing factor-1 promotes colorectal carcinogenesis by causing oxidative stress, DNA damage and intestinal permeability alteration.

Background: Bacterial toxins are emerging as promising hallmarks of colorectal cancer (CRC) pathogenesis. In particular, Cytotoxic Necrotizing Factor 1 (CNF1) from E. coli deserves special consideration due to the significantly higher prevalence of this toxin gene in CRC patients with respect to healthy subjects, and to the numerous tumor-promoting effects that have been ascribed to the toxin in vitro.

Nb(V)-containing saponite: A versatile clay for the catalytic degradation of the hazardous organophosphorus pesticide paraoxon under very mild conditions.

A synthetic saponite clay containing structural Nb(V) metal centres (NbSAP) was investigated in the abatement of paraoxon-ethyl, an anti-cholinergic organophosphorus pesticide, under mild conditions (neutral pH, room temperature and ambient pressure) in heterogenous phase, without additional basic additives. The material was selected according to its high surface acidity and ease of preparation through a one-step hydrothermal synthesis. The presence of Nb(V) ions played a crucial role in efficiently catalysing the degradation of aggressive chemical substrates.

A Compressive Armchair (OTO) to Perform Deep Pressure Therapy in Children With Autism Spectrum Disorder: User-Centered Design and Feasibility Study.

Background: Deep pressure therapy (DPT) is widely used to reduce anxiety in children with autism spectrum disorder (ASD), but evidence of its efficacy is limited.

Objective: This study aims to design a usable, nonstigmatizing compressive armchair that can be easily controlled, electronically, by the user.

Methods: A user-centered approach was used to assess the usability of the device.

Voice quality after open partial horizontal laryngectomy vs. total laryngectomy with voice prosthesis: a comparative study.

Objectives: The aim of this study is to compare voice outcomes in open partial horizontal laryngectomy vs. total laryngectomy (TL) with voice prosthesis.

Methods: In this retrospective monocentric study patients undergoing OPHL or TL with voice prosthesis were enrolled during the usual oncological follow-up consultations at the Otolaryngology and Audiology Unit of a University Hospital in the period between July 2022 and June 2023.

Inhibitory activity of some short-chain aliphatic aldehydes on pheromone and ammonium carbonate-mediated attraction in olive fruit fly, Bactrocera oleae.

Background: The olive fruit fly (OFF), Bactrocera oleae (Rossi), is the main insect pest of olive trees worldwide. Legislation limits to the use of some synthetic larvicidal insecticides is leading to the development of new control options for preventive control of adult flies. In the present study, the biological activity of four short-chain aliphatic aldehydes, namely hexanal, (E)-2-hexenal, heptanal and (E)-2-heptenal, previously reported as repellents to the OFF adults was investigated.