Publications by authors named "M T Garcia-Dominguez"
Cerebral autoregulation (CA) is the mechanism that maintains stable cerebral blood flow (CBF) despite fluctuations in systemic blood pressure, crucial for brain homeostasis. Recent evidence highlights distinct regional variations in CA between the anterior (carotid) and posterior (vertebrobasilar) circulations. Non-invasive neuromonitoring techniques, such as transcranial Doppler, transfer function analysis, and near-infrared spectroscopy, facilitate the dynamic assessment of CBF and autoregulation.
View Article and Find Full Text PDFSpectrum of delayed post-hypoxic leukoencephalopathy syndrome: A systematic review.
World J Clin Cases
October 2024
Article Synopsis
- Delayed post hypoxic leukoencephalopathy syndrome (DPHLS) is a rare neurological condition that emerges weeks after hypoxia, causing cognitive and neurological deficits that are challenging to diagnose and treat.
- The study aims to gather and synthesize existing knowledge on DPHLS, focusing on its biological mechanisms, symptoms, diagnostic methods, and management while identifying areas needing more research.
- A review of 73 cases indicated that hypoxia often results from substance overdoses (like benzodiazepines and opioids), with common symptoms including cognitive decline and abnormal neuroimaging findings showing changes in the brain's white matter.
Chronic pain is a debilitating condition frequently observed in the elderly, involving numerous pathological mechanisms within the nervous system. Diminished local blood flow, nerve degeneration, variations in fiber composition, alterations in ion channels and receptors, accompanied by the sustained activation of immune cells and release of pro-inflammatory cytokines, lead to overactivation of the peripheral nervous system. In the central nervous system, chronic pain is strongly associated with the activation of glial cells, which results in central sensitization and increased pain perception.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to investigate the epidemiology and outcomes of multisystem inflammatory syndrome in children (MIS-C) across 16 Latin American countries from August 2020 to June 2022.
- Out of 1239 children with MIS-C, the majority were previously healthy, with common symptoms including abdominal pain and conjunctival injection, and nearly half required intensive care.
- The overall death rate was 4.88%, notably higher for those not initially diagnosed with MIS-C, emphasizing the need for improved awareness and early detection of the syndrome.
Enkephalins, a subclass of endogenous opioid peptides, play a pivotal role in pain modulation. Enkephalins primarily exert their effects through opioid receptors located widely throughout both the central and peripheral nervous systems. This review will explore the mechanisms by which enkephalins produce analgesia, emotional regulation, neuroprotection, and other physiological effects.
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