Publications by authors named "M T Fonte"
Article Synopsis
- Around 90% of varicella (chickenpox) infections are mild, but adults can experience more severe cases, prompting a study in Florence, Italy, to assess immunity levels post-vaccination.
- A survey of 430 adults (ages 18-94) showed that 89.5% tested positive for varicella antibodies, with no significant differences based on sex or nationality.
- The findings indicated that while vaccination efforts have improved immunity, there is still a notable susceptibility (11.6%) among women aged 18-49, emphasizing the need for ongoing vaccination campaigns and awareness.
Article Synopsis
- A study was conducted to understand the prevalence and characteristics of noninvasive Group A Streptococcus (nGAS) infections in children aged 0-16 years in the post-COVID-19 era, analyzing data from surveys sent to parents of 3580 children in June 2023.
- Results showed that 20.3% of children had GAS infections, predominantly affecting those aged 3-6, with common symptoms including sore throat and fever, and most infections confirmed via rapid antigen detection tests.
- Treatment was primarily antibiotic-based, with amoxicillin and amoxicillin/clavulanate being the most common, while only 34% of children had received influenza vaccinations,
Drug repurposing and rescuing have been widely explored as cost-effective approaches to expand the portfolio of chemotherapeutic agents. Based on the reported antitumor properties of both trans-cinnamic acids and quinacrine, an antimalarial aminoacridine, we explored the antiproliferative properties of two series of N-cinnamoyl-aminoacridines recently identified as multi-stage antiplasmodial leads. The compounds were evaluated in vitro against three cancer cell lines (MKN-28, Huh-7, and HepG2), and human primary dermal fibroblasts.
View Article and Find Full Text PDFIntroduction: Despite global immunization efforts, rubella remains a public health concern, particularly in high- and middle-income countries. This study focused on rubella seroprevalence in the province of Florence, Italy, aiming to identify susceptibility clusters, especially among women in their childbearing age.
Methods: A cross-sectional study was conducted between April 2018 and December 2019, enrolling 430 adult subjects (age over 18 years).
4,9-diaminoacridines with reported antiplasmodial activity were coupled to different trans-cinnamic acids, delivering a new series of conjugates inspired by the covalent bitherapy concept. The new compounds were more potent than primaquine against hepatic stages of Plasmodium berghei, although this was accompanied by cytotoxic effects on Huh-7 hepatocytes. Relevantly, the conjugates displayed nanomolar activities against blood stage P.
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