Current practice variations in venous thromboembolism prophylaxis for adolescents with severe traumatic brain injury: Trauma center type matters.

Background: While severe traumatic brain injury (TBI) faces an increased risk of venous thromboembolism (VTE), pharmacological VTE prophylaxis might be significantly delayed because of concerns for TBI progression. We aimed to assess practice variations in the rate and timing of VTE prophylaxis for adolescent patients with severe TBI between different trauma center types.

Methods: This retrospective cohort study using the American College of Surgeon Trauma Quality Improvement Program database (2017-2021) included patients aged 14 to 18 years with severe TBI.

Mass Spectrometry With Data-Independent Acquisition for the Identification of Target Antigens in Membranous Nephropathy.

Rationale & Objective: In recent years, the strategy of using laser microdissection and mass spectrometry (LCM/MS) has expanded the landscape of antigens associated with membranous nephropathy (MN). Specific associations with phenotypes, diseases and sometimes reversible triggers led to an antigen-based classification of MN, informing precision medicine and highlighting for the potential value of routine use of proteomics in classifying MN. This study aimed at reproducing and further improving the original LCM/MS for antigen detection in MN.

Addressing contemporary threats in anonymised healthcare data using privacy engineering.

Cyber-attacks on healthcare entities and leaks of personal identifiable information (PII) are a growing threat. However, it is now possible to learn sensitive characteristics of an individual without PII, by combining advances in artificial intelligence, analytics, and online repositories. We discuss privacy threats and privacy engineering solutions, emphasizing the selection of privacy enhancing technologies for various healthcare cases.