Associations of Device-Measured Physical Activity and Sedentary Time With Neural Responses to Visual Food Cues in Adults: A Functional Magnetic Resonance Imaging Study.

Self-reported physical activity is associated with lower brain food cue responsiveness in reward-related regions, but relationships utilizing objective physical activity measurement tools have not been explored. This cross-sectional study examined whether device-measured moderate-to-vigorous intensity physical activity and sedentary time are related to neural responses to visual food cues using functional magnetic resonance imaging. Fifty-one healthy adults (30 men, 21 women; mean ± SD: age 26 ± 6 years; body mass index 24.

Peptidomic and proteomic analysis of precision-cut lung slice supernatants.

The precision-cut lung slice (PCLS) model is an ex vivo tissue system that has been used to model disease and examine the effects of exogenous compounds. Few studies have been carried out on the complement of proteins (proteome) and peptides (peptidome) secreted by PCLS and other tissue sections, during tissue culture, although such data are likely to provide critical information on the biology of tissue slices and the changes these undergo. In this study, a workflow was developed to examine the peptidome and proteome of PCLS supernatants using a modified single-pot, solid-phase-enhanced sample preparation (SP3) workflow.

Safety and effectiveness of the anti-amyloid monoclonal antibody (mAb) drug lecanemab for early Alzheimer's disease: The pharmacovigilance perspective.

The development of humanized IgG1 anti-amyloid monoclonal antibodies, such as lecanemab, provides a promising novel treatment pathway with potential disease-modifying effects for patients with early Alzheimer's disease (AD). Lecanemab, which gained marketing approval by the United States Food and Drug Administration (US FDA) in July 2023, has since been approved in multiple countries, including the United Kingdom (UK). The decision by the UK's Medicines and Healthcare products Regulatory Agency (MHRA) to approve lecanemab in August 2024 followed similar regulatory decisions in the US and Japan.

Design and Application of an Imprinted Polymer Sensor for the Dual Detection of Antibiotic Contaminants in Aqueous Samples and Food Matrices.

An innovative polymer-based dual detection microfluidic platform has been developed for the accurate and reliable sensing of trace amounts of antibiotic tetracycline in environmental and food samples. This was achieved through the production of a bespoke polymeric material formed via an imprinting technique using a fluorescent dye. Thus, this enables dual detection of tetracycline, both thermally, via analyzing the heat-transfer resistance at the solid-liquid interface, and optically, through the inner filter effect.