Asymmetric dimethylarginine (ADMA) elevation and arginase up-regulation contribute to endothelial dysfunction related to insulin resistance in rats and morbidly obese humans.

Key Points: The presence of insulin resistance (IR) is determinant for endothelial dysfunction associated with obesity. Although recent studies have implicated the involvement of mitochondrial superoxide and inflammation in the defective nitric oxide (NO)-mediated responses and subsequent endothelial dysfunction in IR, other mechanisms could compromise this pathway. In the present study, we assessed the role of asymmetric dimethylarginine (ADMA) and arginase with respect to IR-induced impairment of endothelium-dependent vasodilatation in human morbid obesity and in a non-obese rat model of IR.

[Increased risk of obesity and central obesity in sedentary postmenopausal women].

Aims: To establish the influence of a sedentary behavior (sit time) on body composition in elderly women from Aragón.

Methods: A total of 457 women participated in the study. Hours of walking were used to define the active behavior (> 1 vs.