A New Approach for Complex Upper Limb Revisions Utilizing the Clavicula Pro Humero Technique: A Case Report.

Case: A complex case is described involving limb salvage using a combination of the clavicula pro humero technique with a free vascularized fibular graft to span the defect following a failed megaprosthetic reconstruction. This is believed to be the first description of this approach for a very difficult problem.

Conclusion: In the setting of infection and minimal bone stock, conventional reconstruction options for the proximal aspect of the humerus were unsatisfactory.

XI-006 induces potent p53-independent apoptosis in Ewing sarcoma.

There is an imperious need for the development of novel therapeutics for the treatment of Ewing sarcoma, the second most prevalent solid bone tumour observed in children and young adolescents. Recently, a 4-nitrobenzofuroxan derivative, XI-006 (NSC207895) was shown to diminish MDM4 promoter activity in breast cancer cell lines. As amplification of MDM4 is frequently observed in sarcomas, this study examined the therapeutic potential of XI-006 for the treatment of Ewing and osteosarcoma.

Primary osteosarcoma of the clavicle and the perils of bone biopsy.

We present a rare case of delayed diagnosis of osteosarcoma of the medial clavicle in a young man. He presented following a pathological fracture with a falsely reassuring core and fine-needle aspiration biopsy. The initial biopsy was suggestive of an aneurysmal bone cyst and was therefore treated conservatively without further follow-up.

Multicentric myofibroblastic sarcoma.

We report a case of synchronous, multicentric low-grade myofibroblastic sarcoma presenting in a 62-year-old man. He initially presented with inflammatory symmetric polyarthritis and adhesive capsulitis of his shoulder and hips bilaterally and did not respond to a trial of disease modifying antirheumatic drugs. Over a period of several years he developed progressive restriction of both knees and nodules on his hands, both knees and back.