Development of a Vaping Cessation Text Messaging Intervention for Latino Young Adults: A Participatory Research Approach.

Objective: Describe the participatory research procedures of developing , a vaping cessation text messaging intervention for Latino young adults, available in English and Spanish.

Methods: Using community-based recruitment strategies, we convened a Community Advisory Board (CAB) of eight Latino young adults (ages 18-25) with different vaping experiences (never users, ex-users, and current users of e-cigarettes). Members held a series of working meetings to adapt , a smoking cessation text messaging intervention, for vaping cessation.

BECN1 protein expression is associated with poor survival in triple negative locally advanced breast cancer.

Objective: The role that Beclin 1 (BECN1) plays in the development and progression of cancer mediated by autophagy, as well as its differential expression in breast cancer cell lines and mammary tumor tissue according to the molecular subtype, has been demonstrated. The objective of this study was to evaluate the association of BECN1 cytoplasmic expression with clinical and pathologic response, recurrence, disease-free survival (DFS) and overall survival (OS) in patients with locally advanced breast cancer (LABC), according to immunophenotype.

Patients And Methods: 64 patients with non-triple negative LABC and 20 patients with triple negative LABC who received preoperative chemotherapy were included in an observational, analytical and retrospective study to evaluate the cytoplasmic expression of BECN1 protein by immunohistochemistry in microarrays of breast cancer tissue obtained before treatment.

[The use of biomarkers in breast cancer].

Advances in the understanding of molecular biology of cancer have allowed that in the last 30 years some biomarkers in cancer have managed to be transferred from the laboratory to clinical practice and have been established as extremely important tools in the management of breast cancer patients. In this review are presented some biomarkers that are routinely used in clinical oncology practice and have a well-established clinical value to direct treatment and establish prognosis in patients with breast cancer, such as ER-alpha (estrogen receptor alpha), PR (progesterone receptor), HER2 (Human Epidermal Growth Factor Receptor 2), Ki-67 (Marker Of Proliferation Ki-67), and other biomarkers, such as multigenic signatures, which are used more and more frequently, due to the clinical value shown in various randomized clinical trials and for being increasingly accessible in daily clinical practice. Given the considerable importance of breast cancer in public health, it is necessary to be updated with respect to current biomarkers that have a use in clinical practice and that can serve as tools to provide patients with a more personalized treatment, as well as to know their prognosis.

[Insights about uncertainty in genetic counseling].

Genetic counseling is an information process to help people in the understanding and adaptation to the medical, psychological and family implications of the genetic contribution in diseases. This counseling encompasses all sorts of patients. This represents a challenge in the daily work of the medical geneticist, because giving information in a meaningful way to the patient and his family implies an emotional and psychological burden.

[Relapsing risk and obstetric-neonatal outcome in pregnancy and systemic lupus erythematosus].

Objective: to assess the effect of pregnancy on systemic lupus erythematosus (SLE) activity, and the obstetric/neonatal outcome.

Methods: historic cohort including 24 female SLE patients who became pregnant. For every pregnant/puerperal period, the presence of lupus relapse, mean relapse, Mex-SLEDAI score and prednisone dose were compared.