Publications by authors named "M T Capalbo"
Article Synopsis
- Systemic inflammation raises the risk of mortality in hospitalized older patients, especially in the context of age-related diseases and infections like COVID-19.
- Inflammatory biomarkers such as the C-reactive protein to albumin ratio (CAR) and various prognostic scores (GPS, mGPS, hs-mGPS) effectively predict short-term mortality but are often underused for this purpose.
- The study involving 3,206 geriatric patients found that higher CAR and higher GPS scores significantly correlated with increased mortality risk, especially in men, indicating that these inflammatory markers can help assess in-hospital mortality risk in older adults.
Possible Role of Tauroursodeoxycholic Acid (TUDCA) and Antibiotic Administration in Modulating Human Gut Microbiota in Home Enteral Nutrition Therapy for the Elderly: A Case Report.
Int J Mol Sci
June 2024
Tauroursodeoxycholic acid (TUDCA) increases the influx of primary bile acids into the gut. Results obtained on animal models suggested that Firmicutes and Proteobacteria phyla are more resistant to bile acids in rats. As part of a pilot study investigating the role of probiotics supplementation in elderly people with home enteral nutrition (HEN), a case of a 92-year-old woman with HEN is reported in the present study.
View Article and Find Full Text PDFBackground: Prognostic risk stratification in older adults with type 2 diabetes (T2D) is important for guiding decisions concerning advance care planning.
Materials And Methods: A retrospective longitudinal study was conducted in a real-world sample of older diabetic patients afferent to the outpatient facilities of the Diabetology Unit of the IRCCS INRCA Hospital of Ancona (Italy). A total of 1,001 T2D patients aged more than 70 years were consecutively evaluated by a multidimensional geriatric assessment, including physical performance evaluated using the Short Physical Performance Battery (SPPB).
The ability to image human tissue samples in 3D, with both cellular resolution and a large field of view (FOV), can improve fundamental and clinical investigations. Here, we demonstrate the feasibility of light-sheet imaging of ~5 cm sized formalin fixed human brain and up to ~7 cm sized formalin fixed paraffin embedded (FFPE) prostate cancer samples, processed with the FFPE-MASH protocol. We present a light-sheet microscopy prototype, the cleared-tissue dual view Selective Plane Illumination Microscope (ct-dSPIM), capable of fast 3D high-resolution acquisitions of cm scale cleared tissue.
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