Publications by authors named "M T Canales"
Importance: Asymptomatic blood pressure (BP) elevations in the hospital are commonly treated with as-needed BP medications, including recurring as-needed and 1-time administration. Veterans represent a population at risk of ischemic events from rapid lowering of BP, but the impact of as-needed BP medication use in this population is unknown.
Objective: To assess the risks of acute kidney injury (AKI) and other outcomes from as-needed BP medication administration in a hospitalized veteran cohort.
Asymptomatic IgM gammopathy encompasses IgM monoclonal gammopathy of undetermined significance (MGUS) and asymptomatic Waldenström macroglobulinemia (AWM), both having a risk of progression to symptomatic disease. Here, we assessed the risk of progression and the mortality of 956 patients with asymptomatic IgM gammopathy across 25 Spanish centers. After a median follow-up of 5.
View Article and Find Full Text PDFMolecular dynamics simulations at constant temperature and pressure were carried out to investigate the structural, dynamical, and dielectric properties of succinonitrile in its plastic and liquid phases at several thermodynamic states. A six-site united atom model was employed with a force field incorporating an intramolecular torsional term that accurately describes gauche and trans conformers. Analysis of the radial distribution function showed that succinonitrile adopts a body-centered cubic arrangement below its melting point, transitioning to a less ordered state in the liquid phase.
View Article and Find Full Text PDFArticle Synopsis
- Dermoscopy is being evaluated as a non-invasive method to diagnose demodicosis, but previous studies vary in their testing standards and positivity criteria.
- A study reviewed 64 patients, comparing dermoscopic findings with skin scraping results, and found a strong correlation between certain dermoscopic signs (like Demodex tails) and the presence of mites, suggesting dermoscopy could be sufficient for diagnosis.
- The study calculated performance indicators showing that specific dermoscopic signs have high positive likelihood ratios, indicating they could reliably indicate demodicosis.
Article Synopsis
- Up to 46% of patients with suspected autoimmune limbic encephalitis don’t test positive for known central nervous system antibodies, prompting the development of a new cell-based assay (CBA) for detecting novel neural antibodies using human-induced pluripotent stem cells (hiPSCs).
- The study involved testing serum and cerebrospinal fluid from 99 patients with inflammatory and non-inflammatory neurological diseases to identify IgG binding to hiPSC-derived neurons and astrocytes using advanced fluorescence techniques.
- The CBA successfully detected neural-specific antibodies in 19 out of 99 patients, with a higher prevalence in those with inflammatory neurological diseases compared to non-inflammatory cases, underscoring its potential in identifying previously unknown autoantibodies.