Publications by authors named "M T Cairns"
Oxidative stress from environmental exposures is thought to play a role in neurodevelopmental disorders; therefore, understanding the underlying molecular regulatory network is essential for mitigating its impacts. In this study, we analysed the competitive endogenous RNA (ceRNA) network mediated by circRNAs, a novel class of regulatory molecules, in an SH-SY5Y cell model of oxidative stress, both prior to and during neural differentiation, using RNA sequencing and in silico analysis. We identified 146 differentially expressed circRNAs, including 93 upregulated and 53 downregulated circRNAs, many of which were significantly co-expressed with mRNAs that potentially interact with miRNAs.
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- Morton neuroma (MN) is a common condition diagnosed through various subjective features and physical tests, and this systematic review aimed to evaluate their diagnostic accuracy.
- The review included 9 studies and found that a patient's report of clicking is highly specific for MN, while the modified webspace tenderness test is highly sensitive in ruling it out.
- Despite the findings, the review's conclusions are limited by a small number of studies and potential bias, emphasizing the need for more comprehensive research on MN diagnostics.*
Approximately 85,000 adolescent and young adults (AYAs; age 15-39) are diagnosed with cancer in the United States annually. Experiencing a cancer diagnosis as an AYA can substantially impact social connections and social health. This paper describes the design and protocol of an observational study to prospectively assess social health and its association with physical activity and quality of life among AYAs after a cancer diagnosis.
View Article and Find Full Text PDFDigital transformation has led to an abundance of digital health technologies (DHTs) readily available for Physiotherapists. In July 2020, the Physiotherapy department at a London NHS Trust implemented a mobile health (mHealth) exercise application (app), Physitrack. This service evaluation aims to evaluate patient experience and identify any barriers to using Physitrack/PhysiApp in musculoskeletal (MSK) Physiotherapy.
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- The study assessed the effectiveness of bivalent and monovalent mRNA COVID-19 boosters among UK healthcare workers from October 2023 to March 2024 during the circulation of the XBB.1.5 and JN.1 variants.
- Among 2867 participants, about half received a booster, and 19% experienced confirmed infections; the monovalent booster showed better effectiveness compared to the bivalent one, especially in the first two months post-vaccination.
- Results indicated that recent infections boosted immunity, and the findings suggest that tailored vaccines for circulating variants could be beneficial for seasonal immunization among healthcare workers.