Biochemical responses in mice induced by saxitoxins extracted from the cockles Acanthocardia tuberculatum.

Harmful algae blooms have increased in frequency and geographic range in recent decades, and they produce toxins strains such as saxitoxins (STXs). they block voltage-gated sodium channels and can lead to several poisonings and the death of organisms that pose a significant risk to public and environmental health. The study of STXs toxicity has been carried out but little is known about the response of antioxidant enzymes activities to STXs in mice.

The Proof-of-Concept of MBA121, a Tacrine-Ferulic Acid Hybrid, for Alzheimer's Disease Therapy.

Great effort has been devoted to the synthesis of novel multi-target directed tacrine derivatives in the search of new treatments for Alzheimer's disease (AD). Herein we describe the proof of concept of MBA121, a compound designed as a tacrine-ferulic acid hybrid, and its potential use in the therapy of AD. MBA121 shows good -amyloid (A) anti-aggregation properties, selective inhibition of human butyrylcholinesterase, good neuroprotection against toxic insults, such as A, A, and HO, and promising ADMET properties that support translational developments.

Germline mutations of B-Raf proto-oncogene and pathological implications in prostate cancer: observational study.

Unlabelled: B-Raf proto-oncogene has been found in a variety of neoplasms. BRAF stimulation can promote tumour proliferation through the activation of the MAP/ERK kinase pathway. This study aimed to determine the germline spectra of BRAF and the association with pathological criteria of prostate tumours.

Cross Dataset Analysis for Generalizability of HRV-Based Stress Detection Models.

Stress is an increasingly prevalent mental health condition across the world. In Europe, for example, stress is considered one of the most common health problems, and over USD 300 billion are spent on stress treatments annually. Therefore, monitoring, identification and prevention of stress are of the utmost importance.

Comparison of Stress Detection through ECG and PPG signals using a Random Forest-based Algorithm.

Stress has been classified as the health epidemic of the 21st century with an increasingly active research interest within the fields of psychology, neuroscience, medicine, and more recently affective computing. At present, stress is identified through cortisol levels in saliva but there is no unanimously accepted standard for continuous stress evaluation. With recent development in wearable sensors, many scientists are interested in stress identification through physiological signals such as the Heart rate variability (HRV).