Publications by authors named "M T Bazelier"
Antibiotic Utilization Among People With Multiple Sclerosis in the Netherlands, 2018-2020.
Pharmacoepidemiol Drug Saf
December 2024
Purpose: The purpose of this study was to describe the intensity and patterns of antibiotic drug use among people with multiple sclerosis (pwMS) in the Netherlands.
Methods: People with prevalent MS between 1 January 2018 and 31 December 2020 were identified using ambulatory hospital records from the PHARMO Database Network that contains routinely collected healthcare data from the Netherlands. Out-patient pharmacy dispensing data were used to assess type of antibiotic, dosage, and amounts dispensed.
Article Synopsis
- Real-world evidence (RWE) is being increasingly utilized in medical regulatory decisions, but there are ongoing concerns about its reproducibility and validity due to diversity across real-world data sources (RWDS).
- This study aimed to identify practices and tools for collecting and reporting diversity in RWDS, as well as to explore how leveraging this diversity can enhance the quality of evidence in pharmacoepidemiology.
- The analysis of 91 selected documents revealed 12 key topics about RWDS diversity, highlighting opportunities and challenges, ultimately providing a foundation for better guidance on data reporting to improve the replicability and validity of RWE.
Purpose: To describe and categorize detailed components of databases in the Neurological and Mental Health Global Epidemiology Network (NeuroGEN).
Methods: An online 132-item questionnaire was sent to key researchers and data custodians of NeuroGEN in North America, Europe, Asia and Oceania. From the responses, we assessed data characteristics including population coverage, data follow-up, clinical information, validity of diagnoses, medication use and data latency.
Aims: Low-dose rivaroxaban has been indicated for the management of atherosclerotic cardiovascular disease (ASCVD) after recent (2019-2020) updates to European guidelines. We aimed to describe prescription trends of low-dose rivaroxaban in ASCVD patients over the period 2015-2022 in two European countries, to compare the trends before and after guideline changes, and to determine the characteristics of users.
Methods: In a cross-sectional interrupted time series analysis, utilization of low-dose rivaroxaban (2.
Background: People with multiple sclerosis (pwMS) have an increased risk of infections; risk factors include underlying disease, physical impairment and use of some disease-modifying treatments.
Objective: To quantify changes in population-level infection rates among pwMS and compare these to the general population and people with rheumatoid arthritis (pwRA), and identify patient characteristics predictive of infections after MS diagnosis.
Methods: We conducted a multi-database study using data on 23,226 people with MS diagnosis from the UK Clinical Practice Research Datalink Aurum and GOLD (January 2000-December 2020).