Publications by authors named "M Szuplewska"

Article Synopsis
  • The study focuses on a specific bacterial species that can cause opportunistic infections in humans, making it a useful model for understanding how bacteria can switch from living harmlessly to becoming pathogenic.
  • Researchers conducted a comprehensive analysis of the genomic sequences of seven bacterial isolates, discovering a complex structure with several extrachromosomal elements, including a new type of mobile genetic element.
  • Key findings include the identification of unique virulence genes, notably the URE gene cluster related to ureolytic activity, highlighting the significance of the flexible genome in influencing the bacterium's ability to cause infections.
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Microorganisms assigned as Cronobacter are Gram-negative, facultatively anaerobic, bacteria widely distributed in nature, home environments, and hospitals. They can also be detected in foods, milk powder, and powdered infant formula (PIF). Additionally, as an opportunistic pathogen, Cronobacter may cause serious infections, sometimes leading to the death of neonates and infants.

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The rapidly emerging phenomenon of antibiotic resistance threatens to substantially reduce the efficacy of available antibacterial therapies. Dissemination of resistance, even between phylogenetically distant bacterial species, is mediated mainly by mobile genetic elements, considered to be natural vectors of horizontal gene transfer. Transposable elements (TEs) play a major role in this process-due to their highly recombinogenic nature they can mobilize adjacent genes and can introduce them into the pool of mobile DNA.

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Partitioning systems ensure the stable inheritance of bacterial low-copy-number replicons, such as chromosomes, chromids, and megaplasmids. These loci consist of two genes encoding partition proteins A and B, and at least one centromere-like sequence. In chromids and megaplasmids, partitioning systems are often located in the vicinity of replication systems.

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Bacteria of the genus (phylum ) include both human and animal pathogens, as well as saprophytic strains. A common component of spp. genomes are plasmids, i.

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