Publications by authors named "M Syzdol"
Introduction: Cell therapy has the potential to improve symptoms and clinical outcomes in refractory angina (RFA). Further analyses are needed to evaluate factors influencing its therapeutic effectiveness.
Aim: Assessment of electromechanical (EM) parameters of the left ventricle (LV) and investigation of correlation between EM parameters of the myocardium and response to CD133+ cell therapy.
Article Synopsis
- - The study investigates the relationship between bone metabolism factors and myocardial injury in STEMI patients by analyzing various serum markers and microRNA expressions at two time points: after 4 days and 3 months post-myocardial infarction.
- - A total of 25 STEMI patients were enrolled, and measurements included osteogenesis/osteolysis factors and microRNA levels, with cardiac function assessed through MRI.
- - The findings revealed no significant changes in the levels of these factors or microRNAs over the 3-month period, and there was no correlation with improvements in left ventricular function, although a negative correlation was found between osteoprotegerin levels and left ventricular ejection fraction in the acute phase.
Background: Acute myocardial infarction (AMI) and coronary artery bypass graft (CABG) surgery are associated with a pathogen-free inflammatory response (sterile inflammation). Complement cascade (CC) and bioactive sphingolipids (BS) are postulated to be involved in this process.
Aim: The aim of this study was to evaluate plasma levels of CC cleavage fragments (C3a, C5a, and C5b9), sphingosine (SP), sphingosine-1-phosphate (S1P), and free hemoglobin (fHb) in AMI patients treated with primary percutaneous coronary intervention (pPCI) and stable coronary artery disease (SCAD) undergoing CABG.
Background: Clinical studies have suggested increased risk of thrombotic events after planned cessation of clopidogrel therapy, due to increased platelet reactivity (platelet rebound); however, in many studies platelet function was not assessed before introducing clopidogrel. Patients who are scheduled to stop clopidogrel therapy, do it abruptly, so a gradual drug cessation might provide a beneficial treatment strategy.
Aim: To determine whether a clopidogrel discontinuation results in platelet rebound hyperaggregability with increased activity compared to pre-treatment values and to assess whether abrupt or tapering clopidogrel cessation may affect platelet reactivity.