Effector CD8 T cell differentiation in primary and breakthrough SARS-CoV-2 infection in mice.

The nature of the effector and memory T cell response in the lungs following acute SARS-CoV-2 infections remains largely unknown. To define the pulmonary T-cell response to COVID-19, we compared effector and memory T-cell responses to SARS-CoV-2 and influenza A virus (IAV) in mice. Both viruses elicited potent effector T cell responses in lungs, but memory T cells showed exaggerated contraction in SARS-CoV-2-infected mice.

Intraventricular pressure and volume during conventional and automated head-up CPR.

Background: Active compression-decompression (ACD) CPR, an impedance threshold device (ITD) and automated head and thorax elevation, collectively termed AHUP-CPR, increases cerebral and coronary perfusion pressures, brain blood flow, end-tidal CO2 (ETCO2) and cerebral oximetry (rSO2) in animal models compared with conventional (C) CPR. We tested the hypothesis that cardiac stroke volume (SV) is higher with AHUP-CPR versus C-CPR or ACD + ITD in a porcine cardiac arrest model.

Methods: Farm pigs (n = 14) were sedated, anesthetized, and ventilated.

Docking and Molecular Dynamics Studies on Anticancer Activities of Flavonoids as Inhibitors of CDK2 and CDK9.

Background: Flavonoids express a wide range of medicinal properties, our study presented results on the anticancer activity of selected compounds using studies.

Objective: In this article, studies were carried out to find promising anticancer lead among selected flavonoid compounds.

Methods: Here, we carried out molecular docking and MD simulation for anticancer screening of flavonoid derivatives against CDK2 and CDK9 proteins.

Impact of Smartphone Usage on Sleep in Adolescents: A Clinically Oriented Review.

Smartphones are an integral part of our lives due to benefits, such as easy accessibility to information, social connectivity, workplace/financial applications, and entertainment including games. The many benefits of a smartphone, like connectivity, increased productivity, availability of information, and portability are however balanced by negative health consequences. Excessive screen time can have multiple negative consequences, the most important of which are reduced time spent in socialization and sleep.

Diversifying T-cell responses: safeguarding against pandemic influenza with mosaic nucleoprotein.

Unlabelled: Pre-existing T-cell responses have been linked to reduced disease severity and better clinical outcomes during the 2009 influenza pandemic and the recent COVID-19 pandemic. We hypothesized that diversifying T-cell responses, particularly targeting conserved viral proteins such as the influenza A virus (IAV) nucleoprotein (NP), could protect against both epidemic and pandemic IAV strains. To test this, we created a mosaic nucleoprotein (MNP) by synthesizing a sequence that maximized the representation of 9-mer epitopes from 7422 NP sequences across human, swine, and avian IAVs.