Publications by authors named "M Sumanth"
Natural radionuclides are universally spread and can be found in varying levels in rock, soil and water depending on the geology. A potential health threat may be caused by them to humans on consumption of water, food and inhalation of air due to the presence of radionuclides. In the present study, an attempt has been made to study the distribution of 238U, 226Ra, 222Rn and 210Po in groundwater samples of Kodagu district, India.
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- The study highlights the need for alternative methods to detect SARS-CoV-2 using self-collected samples without viral transport media (VTM).
- Evaluation involved a cross-sectional study with 125 participants to test various nucleic acid extraction methods from saliva and oral swabs.
- Results showed that the kit-based extraction method (SKE) was the most effective, accurately identifying 93.07% of positive cases, suggesting these simplified methods are a viable and cost-effective option for SARS-CoV-2 testing.
Alpha-1-acid glycoprotein (AGP-1) is a positive acute phase glycoprotein with uncertain functions. Serum AGP-1 (sAGP-1) is primarily derived from hepatocytes and circulates as 12-20 different glycoforms. We isolated a glycoform secreted from platelet-activating factor (PAF)-stimulated human neutrophils (nAGP-1).
View Article and Find Full Text PDFBacterial toxins signaling through Toll-like receptors (TLRs) are implicated in the pathogenesis of many inflammatory diseases. Among the toxins, lipopolysaccharide (LPS) exerts its action via TLR-4 while lipoteichoic acid (LTA) and bacterial lipoproteins such as Braun lipoprotein (BLP) or its synthetic analogue Pam3CSK4 act through TLR-2. Part of the TLR mediated pathogenicity is believed to stem from endogenously biosynthesized platelet-activating factor (PAF)- a potent inflammatory phospholipid acting through PAF-receptor (PAF-R).
View Article and Find Full Text PDFPlatelet-activating factor (PAF) is a potent inflammatory agonist. In Swiss albino mice, intraperitoneal injection of PAF causes sudden death with oxidative stress and disseminated intravascular coagulation (DIC), characterized by prolonged prothrombin time, thrombocytopenia, reduced fibrinogen content, and increased levels of fibrinogen degradation products. However, the underlying mechanism(s) is unknown.
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