In-silico discovery of efficient second-generation drug derivatives with enhanced antihistamine potency and selectivity.

The current study focuses on the potential of second-generation antihistamines, which exhibit fewer side effects compared to first-generation drugs, to block the Histamine H receptor (HR) and mitigate allergic responses. We screened several derivatives of second-generation drugs taking Desloratadine (Deslo) and Acrivastine (Acra) as seed compounds. We performed molecular docking, drug-likeness, quantum chemical calculations, UV-visible and infrared spectroscopy, molecular electrostatic potential (MEP) mapping for understanding drug derivatives potential as efficient drugs and molecular dynamics (MD).

Optimum Nitrogen and Phosphorus Combination Improved Yield and Nutrient Use Efficiency of Sorghum in Saline Soil.

Two-year experiments were conducted to assess the responses of yield and nutrient use efficiency of sorghum to nitrogen and phosphorus under saline soils. Three nitrogen rates (0, 180, and 360 N kg ha) and three phosphorus rates (0, 60, and 120 PO kg ha) were used in this study. Our results showed that nitrogen and phosphorus supply increased SPAD (leaf greenness, 5.

Personalized risk reduction strategies utilizing the diabetes and ramadan risk calculator: a narrative review.

The Diabetes and Ramadan Risk Calculator, developed in 2021, is a pivotal tool for assessing fasting-related risks among patients with diabetes. This ground-breaking innovation offers a quantitative assessment of risk scores during fasting, revolutionizing the landscape of diabetes management during Ramadan. Many components assessed by the calculator are amenable to modification, presenting an opportunity for year-round intervention to mitigate risk scores and subsequent fasting risks.

Dysregulation of GAS5-miRNA-Mediated Signaling Pathways in Cancer Pathobiology: A Comprehensive Exploration of Pathways Influenced by this Axis.

The long non-coding RNA Growth Arrest-Specific 5 (GAS5) is pivotal in modulating key signaling pathways by functioning as a molecular sponge for microRNAs (miRNAs). GAS5 is notably recognized for its antitumor properties, primarily through its ability to sequester oncogenic miRNAs, thereby influencing critical pathways such as p53, Wnt/β-catenin, and PI3K/Akt, all of which are integral to cell proliferation, apoptosis, and metastasis. The disruption of GAS5-miRNA interactions has been implicated in various malignancies, reinforcing its potential as both a biomarker and a therapeutic target.

Reversed Cyclic Behavior of Carbon Nanofiber-Reinforced Concrete Shear Walls.

This study investigates the effects of integrating carbon nanofibers (CNF) into concrete to enhance the mechanical properties and reversed cyclic behavior of framed shear walls, addressing the need for improved seismic performance and durability. Despite the known benefits of CNF in improving concrete properties and enabling structural health monitoring, its application in framed shear walls has been limited. Through the design and testing of nineteen CNFC formulations, this research established a constitutive relationship allowing the Cyclic Softened Membrane Model (CSMM) to be applied to CNFC.