Identification of risk factors related to problematic peripheral neuropathy development in gemcitabine and nab-paclitaxel treatment for pancreatic cancer.

Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect in patients treated with gemcitabine (GEM) and nanoparticle albumin-bound paclitaxel (nab-PTX) for pancreatic cancer, negatively impacting their quality of life. This study aimed to identify risk factors for significant CIPN development in a real-world setting of GEM + nab-PTX treatment to inform effective management strategies.

Methods: Patients with unresectable pancreatic cancer who received GEM + nab-PTX (n = 140) were retrospectively assessed.

Awareness of the risk factors and interventions for dementia among outpatients with diabetes.

Aims/introduction: As the prevalence of diabetes increases with age, the number of elderly patients with diabetes in Japan, a super-aged society, continues to increase. We conducted a survey to investigate the extent to which outpatients with diabetes recognize dementia as a complication of diabetes.

Materials And Methods: A questionnaire was distributed among 777 patients with diabetes to investigate their awareness of dementia and its risk factors.

Severe Hypomagnesemia in a Patient Treated Using Carboplatin Co-Administered with Vonoprazan.

Introduction: We describe a case of severe hypomagnesemia that occurred during treatment with carboplatin (CBDCA) and nanoparticle albumin-bound paclitaxel (nab-PTX) for lung adenocarcinoma when co-administered with vonoprazan.

Case Presentation: A man in his 70s was diagnosed with stage IIIA lung adenocarcinoma and received CBDCA and nab-PTX as the first-line treatment. The patient had been taking omeprazole 10 mg once daily (for >3 years) for gastroesophageal reflux disease, but it was switched to lansoprazole 15 mg because of hospital's adopted medication.

A Case of Neonatal Cytotoxic Lesions of the Corpus Callosum With Subpial Hemorrhage.

Subpial hemorrhage is a rare type of birth-related brain hemorrhage in neonates that can manifest with symptoms such as apnea and seizures. On brain magnetic resonance imaging (MRI), subpial and parenchymal hemorrhages are typically observed but often resolve without lasting sequelae. Cytotoxic lesions of the corpus callosum (CLOCCs) are not as common in neonates as they are in adults and children.