Publications by authors named "M Sudol"
Article Synopsis
- Cardiomyocyte differentiation is regulated by the modulation of BMP/Wnt signaling pathways, with current research focused on understanding how these pathways remove regulatory obstacles during development.* -
- A genome-wide CRISPR screen identified NF2 as a critical factor for early cardiomyocyte specification, demonstrating that NF2 is essential for maintaining cardiomyocyte identity during differentiation.* -
- The study revealed that NF2 works with AMOT to inhibit YAP activation during mesendoderm formation, highlighting their joint role in clearing regulatory barriers necessary for proper cardiac lineage development.*
Biomolecular condensates (BMCs) play important roles incellular structures includingtranscription factories, splicing speckles, and nucleoli. BMCs bring together proteins and other macromolecules, selectively concentrating them so that specific reactions can occur without interference from the surrounding environment. BMCs are often made up of proteins that contain intrinsically disordered regions (IDRs), form phase-separated spherical puncta, form liquid-like droplets that undergo fusion and fission, contain molecules that are mobile, and are disrupted with phase-dissolving drugs such as 1,6-hexanediol.
View Article and Find Full Text PDFBackground: Tissues need to regenerate to restore function after injury. Yet, this regenerative capacity varies significantly between organs and between species. For example, in the heart, some species retain full regenerative capacity throughout their lifespan but human cardiac cells display a limited ability to repair the injury.
View Article and Find Full Text PDFBiomolecular condensates (BMCs) play important roles in cellular structures including transcription factories, splicing speckles, and nucleoli. BMCs bring together proteins and other macromolecules, selectively concentrating them so that specific reactions can occur without interference from the surrounding environment. BMCs are often made up of proteins that contain intrinsically disordered regions (IDRs), form phase-separated spherical puncta, form liquid-like droplets that undergo fusion and fission, contain molecules that are mobile, and are disrupted with phase-dissolving drugs such as 1,6-hexanediol.
View Article and Find Full Text PDFBackground: Frequent scanning of intermittently scanned continuous glucose monitoring (isCGM) devices is associated with improvements in glycemic indices. Limited data is available for its correlation with fear of hypoglycemia (FOH), an established factor affecting quality of life and glycemic control in type 1 diabetes (T1DM).
Aim: The aim of the study was to analyze the association of sensor scanning frequency with FOH and glycemic indices in T1DM patients using isCGM.