Publications by authors named "M Struys"
Background And Objectives: The pharmacokinetics (PK) of piperacillin/tazobactam (PIP/TAZ) is highly variable across different patient populations and there are controversies regarding non-linear elimination as well as the fraction unbound of PIP (f). This has led to a plethora of subgroup-specific models, increasing the risk of misusing published models when optimising dosing regimens. In this study, we aimed to develop a single model to simultaneously describe the PK of PIP/TAZ in diverse patient populations and evaluate the current dosing recommendations by predicting the PK/pharmacodynamics (PD) target attainment throughout life.
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- The study assessed the quality of EMS care by analyzing deployment reports and measuring how time was spent during various phases of EMS operations, raising questions about the relevance of time metrics in evaluating care quality.
- A focused ethnographic approach was used, involving video recordings and interviews, which helped outline the EMS care process through the development of a model known as SPART.
- The results provided insights into the effectiveness of clinical reasoning and the overall quality of care by analyzing the nature, order, and duration of EMS activities across different operational periods (response, on-scene, transport).
Article Synopsis
- Intraoperation hypotension (IOH) during surgery can have negative effects, leading to the routine use of norepinephrine (NE) to manage blood pressure under general anesthesia, although its pharmacokinetics during such conditions are not well understood.
- The study aimed to analyze the pharmacokinetics of NE in healthy volunteers in both awake and general anesthesia states, using a step-up dosing method and measuring plasma concentrations.
- Results indicated that a two-compartment model effectively described NE dynamics, finding that general anesthesia reduced NE clearance by 10%, with weight, age, and session (awake vs. anesthesia) being significant factors affecting its clearance.
Only some subpopulations of natural killer (NK) cells have cytotoxic functionality, and the effects of anesthetics on these subpopulations are unknown. This study aimed to evaluate the in vitro effects of various anesthetics, both alone and in combination, on the distribution and cytotoxic function of NK cells and their subpopulations. Peripheral blood mononuclear cells (PBMCs) from eight healthy volunteers were treated for 4 h in vitro with dexmedetomidine, remifentanil, lidocaine, propofol, sevoflurane, and combinations in clinically relevant concentrations or left untreated.
View Article and Find Full Text PDFObjectives: This study aimed to assess the impact of persistent pulmonary hypertension of the newborn (PPHN) on perioperative morbidity and mortality in patients with dextro-transposition of the great arteries. Secondarily, we evaluated the association between postoperative outcomes and intraoperative variables including the duration of cardiopulmonary bypass, cerebral oxygen desaturation, and hypotension.
Design: Retrospective observational study.