Publications by authors named "M Strubin"
Article Synopsis
- The human Smc5/6 complex is crucial for chromosome stability and also functions as an antiviral factor by binding to and blocking transcription of extrachromosomal DNA.
- It prefers to bind to circular DNA, and its recruitment is influenced by the transcription process, specifically the formation of DNA secondary structures.
- Smc5/6 interacts with positively supercoiled DNA and is found at highly transcribed chromosome sites, revealing its role in managing DNA topology and highlighting how this contributes to antiviral defense.
Childhood Cancer Survivorship Passport Challenges in the European Health Data Space.
Stud Health Technol Inform
August 2024
Innovation in cancer therapy has increased childhood cancer survival rates. However, survivors are still at risk of developing late effects. In the digital transformation of the health sector, the Survivorship Passport (SurPass) can support long-term follow-up care plans.
View Article and Find Full Text PDFIn addition to its role in chromosome maintenance, the six-membered Smc5/6 complex functions as a restriction factor that binds to and transcriptionally silences viral and other episomal DNA. However, the underlying mechanism is unknown. Here, we show that transcriptional silencing by the human Smc5/6 complex is a three-step process.
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