IRE1 is a Promising Therapeutic Target in Pancreatic Cancer.

Pancreatic cancer (PC) is one of the most aggressive malignancies, characterized by an increasing incidence and unfavorable prognosis. Despite recent advances, surgical resection combined with chemotherapy remains the only potentially curative therapeutic option. Therefore, it is of paramount importance to identify novel therapeutic targets and develop effective treatment strategies.

Untargeted blood serum proteomics identifies novel proteins related to neurological recovery after human spinal cord injury.

Background: The discovery of new prognostic biomarkers following spinal cord injury (SCI) is a rapidly growing field that could help uncover the underlying pathological mechanisms of SCI and aid in the development of new therapies. To date, this search has largely focused on the initial days after the lesion. However, during the subacute stage of SCI (weeks to months after the injury), there remains potential for sensorimotor recovery, and numerous secondary events develop in various organs.

Low intraoperative end-tidal carbon dioxide levels are associated with improved recurrence-free survival after elective colorectal cancer surgery.

Study Objective: Higher levels of carbon dioxide (CO) increase the invasive abilities of colon cancer cells in vitro. Studies assessing target values for end-tidal CO concentrations (EtCO) to improve surgical outcome after colorectal cancer surgery are lacking. Therefore, we evaluated whether intraoperative EtCO was associated with differences in recurrence-free survival after elective colorectal cancer (CRC) surgery.