Application of electrochemical biosensors in clinical diagnosis.

Analyses in the clinical area need quick and reliable analytical methods and devices. For this purpose, biosensors can be a suitable option, whereas they are constructed to be simple for use, specific for the target analyte, capable of continuous monitoring and giving quick results, potentially low-costing and portable. In this article, we describe electrochemical biosensors developed for clinical diagnosis, namely for glucose, lactate, cholesterol, urea, creatinine, DNA, antigens, antibodies, and cancer markers assays.

A glucose/hydrogen peroxide biofuel cell that uses oxidase and peroxidase as catalysts by composite bulk-modified bioelectrodes based on a solid binding matrix.

An improved composite bulk-modified bioelectrode setup based on a solid binding matrix (SBM) has been used to develop a glucose/hydrogen peroxide biofuel cell. Fuel is combined through a catalytically promoted reaction with oxygen into and oxidized species and electricity. The present work explores the feasibility of a sugar-feed biofuel cell based on SBM technology.

Amperometric biosensors based on solid binding matrices applied in food quality monitoring.

Solid binding matrix (SBM) based composite transducers have been used for development of series of multibiosensor systems applicable in various fields. Here we present two hybrid three-channel multibiosensors for simultaneous amperometric operation in food quality control, i.e.

Composite transducers for amperometric biosensors. The glucose sensor.

A new concept of a composite transducer for amperometric biosensors based on the use of a solid substance with amphiphilic character (called a solid binding matrix, SBM) is presented. The electrochemical properties of the transducers prepared with five different SBMs and the characteristics and performance of SBM-based glucose sensors prepared by three different methods are described. Biosensor stability is evaluated and discussed.

Arachidonic acid production by Mortierella alpina grown on solid substrates.

Mortierella alpina grown in solid state fermentations on cereal substrates gave up to 16% lipid in the final biomass. Arachidonic was at 50% of total fatty acids, with a yield of 36 mg/g of original substrate. Microbial lipid production was successfully scaled up to use 5-kg dry substrate batches.