Publications by authors named "M Strazzabosco"
Background & Aims: Approximately 40% of patients with Primary Biliary Cholangitis (PBC) show incomplete response to ursodeoxycholic acid, thus needing second-line treatment to prevent disease progression. As no head-to-head comparison study is available, we used a network meta-analysis (NMA) to compare efficacy and safety of available second-line therapies.
Methods: We performed a systematic literature review including randomised, placebo-controlled trials of patients with PBC and incomplete response, or intolerance, to ursodeoxycholic acid, and compared relative risks (RRs) for primary (biochemical response at 52-week) and secondary outcomes [incidence of new-onset pruritus and serious adverse events (SAEs)].
A consistent feature of chronic liver diseases and the hallmark of pathologic repair is the so-called "ductular reaction." This is a histologic abnormality characterized by an expansion of dysmorphic cholangiocytes inside and around portal spaces infiltrated by inflammatory, mesenchymal, and vascular cells. The ductular reaction is a highly regulated response based on the reactivation of morphogenetic signaling mechanisms and a complex crosstalk among a multitude of cell types.
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- This study aimed to compare the effectiveness of 1D and 3D tumor response assessments in predicting median overall survival (mOS) in patients with hepatocellular carcinoma (HCC) receiving immunotherapy.
- A total of 37 patients were analyzed, revealing that 3D assessments (vqEASL and %qEASL) effectively classified patients into groups based on their response to treatment and were better predictors of mOS compared to traditional 1D methods, with the latter showing limited predictive value.
- The findings suggest that 3D quantitative assessment tools like qEASL can improve predictions of survival outcomes and help identify patients who do not respond to immunotherapy, aiding in clinical decision-making.
Background & Aims: The underlying mechanisms and clinical impact of portal microthrombosis in severe COVID-19 are unknown. Intrapulmonary vascular dilation (IPVD)-related hypoxia has been described in severe liver diseases. We hypothesised that portal microthrombosis is associated with IPVD and fatal respiratory failure in COVID-19.
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