Publications by authors named "M Stolarska"
J-domain proteins are critical Hsp70 co-chaperones. A and B types have a poorly understood glycine-rich region (G) adjacent to their N-terminal J-domain (J). We analyzed the ability of J/G segments of yeast Class B Sis1 and a suppressor variant of Class A, Ydj1, to rescue the inviability of sis1-∆.
View Article and Find Full Text PDFMechanosensitivity of cell spread area to substrate stiffness has been established both through experiments and different types of mathematical models of varying complexity including both the mechanics and biochemical reactions in the cell. What has not been addressed in previous mathematical models is the role of cell membrane dynamics on cell spreading, and an investigation of this issue is the goal of this work. We start with a simple mechanical model of cell spreading on a deformable substrate and progressively layer mechanisms to account for the traction dependent growth of focal adhesions, focal adhesion induced actin polymerization, membrane unfolding/exocytosis and contractility.
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- CVM cells migrate along the TVM while being influenced by the extracellular matrix (ECM), and this study focuses on how the protease AdamTS-A impacts this migration.
- Experimental findings indicate that AdamTS-A primarily acts on the sides of CVM cells that aren't in contact with the TVM, particularly at the CVM-ECM interface, influencing migration patterns.
- Unlike its role in other migrating cells, AdamTS-A plays a broader role in CVM cells by cleaving connections to the ECM on multiple sides, facilitating their collective migration.
A child's mouth is the gateway to many species of bacteria. Changes in the oral microbiome may affect the health of the entire body. The aim of the study was to evaluate the changes in the oral microbiome of childhood cancer survivors.
View Article and Find Full Text PDFThe aim of this study was to evaluate the effect of everolimus, a mammalian target of rapamycin (mTOR) inhibitor, on red blood cell parameters in the context of iron homeostasis in patients with tuberous sclerosis complex (TSC) and evaluate its effect on cell size in vitro. Everolimus has a significant impact on red blood cell parameters in patients with TSC. The most common alteration was microcytosis.
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