Polyglycolic acid mesh in experimental renal trauma.

We investigated the efficacy of kidney wrapping with polyglycolic acid (PGA) mesh for control of hemorrhage and preservation of renal function following extensive potentially lethal kidney lacerations in the dog. Wrapping of lacerated kidneys resulted in reapposition of the renal parenchyma and prompt, sustained hemostasis. At 21 days following injury the renal lacerations were well healed.

Hemorrhagic complications of piperacillin therapy.

Clinically significant hemorrhage associated with extended spectrum anti-Pseudomonas penicillins is uncommon. We describe 2 patients with bleeding complications owing to piperacillin. In addition, we review the incidence and mechanism of this adverse reaction, and make suggestions for the management of these patients.

Percutaneous identification and removal of fungus ball from renal pelvis.

Fungus balls in the upper urinary tract are uncommon infectious processes that usually occur in diabetic patients. We report a case of an obstructing fungus ball of the renal pelvis, which was identified and removed successfully by percutaneous techniques.

Comparison of leuprolide and diethylstilbestrol for stage D2 adenocarcinoma of prostate.

In a controlled, prospective, randomized clinical trial, we evaluated the safety and efficacy of leuprolide, a superactive analog of luteinizing hormone releasing hormone, given in a single subcutaneous injection dose of 1 mg per day, versus diethylstilbestrol (DES) 3 mg per day by mouth in patients with previously untreated Stage D2 prostatic adenocarcinoma. Eleven leuprolide patients and 10 DES patients were evaluated for therapeutic response. Eighty per cent of patients in each group experienced subjective improvement in bone pain and urinary obstructive signs and symptoms.

The effect of hormone therapy on peripheral blood leukocytic subset distribution in stage D prostatic cancer patients.

The distribution of mononuclear cell types found in the peripheral blood of patients bearing carcinoma of the prostate were compared by stage and to a control group using monoclonal antibody techniques. Patients with lower stage disease (A, B) had no significant alteration in subset distribution when compared to a control group, while those with higher stage disease (D) had significant deviations. Stage D patients had a decreased representation of helper-inducer T cells and an increased representation of suppressor-cytotoxic T cells, with an overall reduction in the total T cell content.