HPLC-based cytotoxicity profiling and LC-ESIQTOF-MS/MS analysis of .

Introduction: Boiss. (Asteraceae) is an endemic plant to Iran. No reports have studied the cytotoxicity of the plant.

Comparative LC-ESIMS-Based Metabolite Profiling of with and Evaluating Their Hepatotoxicity.

Mill. (Fabaceae) is an important medicinal plant distributed worldwide. (), the officinal species of the genus, is one of the most well-known herbal medicines traditionally used to treat constipation and digestive diseases.

Synthesis, Neuroprotective Effect and Physicochemical Studies of Novel Peptide and Nootropic Analogues of Alzheimer Disease Drug.

Glutamate is an excitatory neurotransmitter in the nervous system. Excessive glutamate transmission can lead to increased calcium ion expression, related to increased neurotoxicity. Memantine is used for treating patients with Alzheimer's disease (AD) due to its protective action on the neurons against toxicity caused by over activation of N-methyl-D-aspartate receptors.

Chemical Conversion of Hardly Ionizable Rhenium Aryl Chlorocomplexes with -Substituted Anilines.

Fast and selective analytical methods help to ensure the chemical identity and desired purity of the prepared complexes before their medical application, and play an indispensable role in clinical practice. Mass spectrometry, despite some limitations, is an integral part of these methods. In the context of mass spectrometry, specific problems arise with the low ionization efficiency of particular analytes.

Physico-chemical characterization of bilirubin-10-sulfonate and comparison of its acid-base behavior with unconjugated bilirubin.

Unconjugated bilirubin (UCB) is the end-product of heme catabolism in the intravascular compartment. Although beneficial for human health when mildly elevated in the body, when present at greater than a critical threshold concentration, UCB exerts toxic effects that are related to its physico-chemical properties, particularly affecting the central nervous system. The aim of the present study was to characterize bilirubin-10-sulfonate (ranarubin), a naturally occurring bile pigment, including determination of its mixed acidity constants (pK).