Publications by authors named "M Stiborova"
The plant extract aristolochic acid (AA), containing aristolochic acids I (AAI) and II (AAII) as major components, causes aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN), unique renal diseases associated with upper urothelial cancer. Recently (Chemical Research in Toxicology 33(11), 2804-2818, 2020), we showed that the metabolism of AAI and AAII in Wistar rats is influenced by their co-exposure (i.e.
View Article and Find Full Text PDFThe environmental pollutant benzo[]pyrene (BaP) is a human carcinogen that reacts with DNA after metabolic activation catalysed by cytochromes P450 (CYP) 1A1 and 1B1 together with microsomal epoxide hydrolase. The azo dye Sudan I is a potent inducer of CYP1A1/2. Here, Wistar rats were either treated with single doses of BaP (150 mg/kg bw) or Sudan I (50 mg/kg bw) alone or with both compounds in combination to explore BaP-derived DNA adduct formation .
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- The study investigates the role of p38-MAPK in mouse preimplantation development, focusing on how it affects the differentiation of the inner cell mass (ICM) and primitive endoderm (PrE) by regulating RNA processing and translation.
- Researchers specifically examine DEAD-box RNA helicase 21 (DDX21), finding that its expression is crucial during blastocyst development and is associated with p38-MAPK activity.
- Results from knockdown experiments reveal that reduced DDX21 leads to significant defects in cell proliferation and differentiation, highlighting its importance in lineage-specific translation regulation in the early stages of mouse embryo development.
The plant extract aristolochic acid (AA), containing aristolochic acid I (AAI) and II (AAII) as major components, causes aristolochic acid nephropathy and Balkan endemic nephropathy, unique renal diseases associated with upper urothelial cancer. Differences in the metabolic activation and detoxification of AAI and AAII and their effects on the metabolism of AAI/AAII mixture in the plant extract might be of great importance for an individual's susceptibility in the development of AA-mediated nephropathies and malignancies. Here, we investigated metabolism of AAI and AAII after ip administration to Wistar rats as individual compounds and as AAI/AAII mixture using high performance liquid chromatography/electrospray ionization mass spectrometry.
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