Accuracy and precision of navigated transcranial magnetic stimulation.

Transcranial magnetic stimulation (TMS) induces an electric field (E-field) in the cortex. To facilitate stimulation targeting, image-guided neuronavigation systems have been introduced. Such systems track the placement of the coil with respect to the head and visualize the estimated cortical stimulation location on an anatomical brain image in real time.

µ-rhythm phase from somatosensory but not motor cortex correlates with corticospinal excitability in EEG-triggered TMS.

Background: Sensorimotor µ-rhythm phase is correlated with corticospinal excitability. Transcranial magnetic stimulation (TMS) of motor cortex results in larger motor evoked potentials (MEPs) during the negative peak of the EEG oscillation as extracted with a surface Laplacian. However, the anatomical source of the relevant oscillation is not clear and demonstration of the relationship is sensitive to the choice of EEG montage.

Towards an objective evaluation of EEG/MEG source estimation methods - The linear approach.

The spatial resolution of EEG/MEG source estimates, often described in terms of source leakage in the context of the inverse problem, poses constraints on the inferences that can be drawn from EEG/MEG source estimation results. Software packages for EEG/MEG data analysis offer a large choice of source estimation methods but few tools to experimental researchers for methods evaluation and comparison. Here, we describe a framework and tools for objective and intuitive resolution analysis of EEG/MEG source estimation based on linear systems analysis, and apply those to the most widely used distributed source estimation methods such as L2-minimum-norm estimation (L2-MNE) and linearly constrained minimum variance (LCMV) beamformers.

Closed-loop optimization of transcranial magnetic stimulation with electroencephalography feedback.

Background: Transcranial magnetic stimulation (TMS) is widely used in brain research and treatment of various brain dysfunctions. However, the optimal way to target stimulation and administer TMS therapies, for example, where and in which electric field direction the stimuli should be given, is yet to be determined.

Objective: To develop an automated closed-loop system for adjusting TMS parameters (in this work, the stimulus orientation) online based on TMS-evoked brain activity measured with electroencephalography (EEG).