TRAIL stabilization and cancer cell sensitization to its pro-apoptotic activity achieved through genetic fusion with arginine deiminase.

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) binds to death receptors and induces apoptosis in various cancer cell lines while sparing normal cells. Recombinant TRAIL has shown good safety and efficacy profiles in preclinical cancer models. However, clinical success has been limited due to poor PK and development of resistance to death receptor-induced apoptosis.

Finding a Hospital's Role in Curbing Chicago's Violence.

Chicago has made national headlines for the more than 780 murders last year and the dozens ofhomicides committed already this year. University of Chicago Medicine is now building the only adult Level I trauma center located on the South Side, one of the city's most violence-plagued communities. Spearheading the effort is SELWYN ROGERS JR.