Publications by authors named "M Stasi"
Article Synopsis
- The study identified 29 compounds from apolar and medium polarity extracts of stem bark and leaves, including three new sesquiterpenes and one new α-ionone glycoside.
- All compounds were characterized using advanced techniques like 1D and 2D NMR and HRESIMS, complemented by DFT/NMR methods for structural analysis.
- In antimicrobial tests against various bacteria, no significant inhibitory activity was found for the crude extracts.
: To evaluate the advanced lens measurement approach (ALMA) formula accuracy using different lens constants available on the user group for laser interference biometry (ULIB) and IOL Con platforms. In this retrospective, comparative, case-series study, 150 eyes of 160 patients with previous myopic Photorefractive Keratectomy (PRK) or laser-assisted in situ keratomileusis (LASIK), who underwent uneventful cataract surgery and IOL implantation, were examined. The ALMA formula was evaluated to calculate the refractive prediction error (PE), analysing four different categories of lens constants: both nominal and optimized A-Constant for SRKT, which are available on the ULIB and IOL Con platforms.
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- Multiple acyl-CoA dehydrogenase deficiency (MADD) is a rare metabolic disorder caused by genetic mutations, affecting the body's ability to process fatty and amino acids, occurring in about 1 in 200,000 live births.
- MADD manifests in three ways: severe neonatal-onset, which may include additional congenital anomalies, and a milder late-onset variant, with diagnosis supported by advanced urine and blood tests.
- Researchers successfully diagnosed a newborn with a unique intronic mutation using whole-genome and RNA sequencing, emphasizing the need to analyze RNA to uncover hidden genetic issues that typical methods might miss.
Dynamic combinatorial chemistry (DCC) creates libraries of molecules that are constantly interchanging in a dynamic combinatorial library. When a library member self-assembles, it can displace the equilibria, leading to emergent phenomena like its selection or even its replication. However, such dynamic combinatorial libraries typically operate in or close to equilibrium.
View Article and Find Full Text PDFOne of science's greatest challenges is determining how life can spontaneously emerge from a mixture of molecules. A complicating factor is that life and its molecules are inherently unstable-RNA and proteins are prone to hydrolysis and denaturation. For the de novo synthesis of life or to better understand its emergence at its origin, selection mechanisms are needed for unstable molecules.
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