Publications by authors named "M Stas"
Article Synopsis
- Decreased expression of vitamin D receptors (VDR) in melanoma and melanocytic naevi compared to normal skin is observed, revealing a potential link to melanoma characteristics.
- A study involving 407 melanoma patients analyzed how VDR expression correlated with vitamin D levels, demographic factors, VDR genetic variants, and tumor pathology.
- Findings showed higher cytoplasmic VDR expression in patients with greater sun exposure and different genetic variants, while lower nuclear VDR expression was associated with tumor characteristics like mitosis and perineural invasion.
Victorins, a family of peptide toxins, produced by the fungal pathogen and responsible for disease of some oat varieties, contain a β-chlorodehydroalanine residue, ΔAla(βCl). To determine the conformational properties of this unique dehydroamino acid, a series of model compounds was studied using X-ray, NMR, and FT-IR methods, supported by theoretical calculations. The ΔAla(βCl) geometrical isomers differ in conformational profile.
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- The study examined how different types of extremity soft-tissue sarcomas (eSTS) responded to isolated limb perfusion (ILP) treatment across 17 specialized centers, focusing on response rates based on imaging and clinical data.
- The analysis included 1109 patients, revealing that undifferentiated pleomorphic sarcoma, synovial sarcoma, and myxofibrosarcoma were the most common eSTS subtypes.
- The results showed that ILP led to a high overall response rate (68%) and limb salvage rate (88%), particularly with better outcomes for Kaposi sarcoma, angiosarcoma, and clear cell sarcoma compared to other subtypes.
Porcine reproductive and respiratory syndrome virus (PRRSV) is a positive-stranded RNA virus, which emerged in Europe and U.S.A.
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- Non-steroidal anti-inflammatory drugs, like sulindac, have shown potential in inhibiting tumor development, with its cytotoxic effects on melanoma cells comparable to traditional chemotherapy drugs like dacarbazine.
- The study examined how sulindac affects the antioxidant enzyme activity and apoptotic protein levels in two melanoma cell lines: COLO 829 and C32.
- Results indicated that sulindac promotes apoptosis in melanotic melanoma cells by altering enzyme activities and the balance of pro-apoptotic (p53, Bax) and anti-apoptotic (Bcl-2) proteins, suggesting its potential use in targeted therapy for melanotic melanoma.