Publications by authors named "M Spotti"
Article Synopsis
- * A study involving 42 patients from various international centers aimed to measure the effectiveness of combining ICIs with chemotherapy, with expectations of improved 6-month progression-free survival (rwPFS) rates.
- * Results revealed a disappointing 6-month rwPFS rate of 30% and a median overall survival of 15.7 months for patients, prompting a call for further research on the efficacy of immunotherapy in mTN-IBC, contrary to earlier expectations regarding its immune-vulnerability.
Purpose: Non-tuberculous mycobacteria (NTM) account for high clinical burden, and treatment can be challenging. Moreover, accessibility of NTM medications varies across centers. These challenges may lead to unplanned therapeutic changes, discontinuations, potentially affecting patient outcomes.
View Article and Find Full Text PDFArticle Synopsis
- * During the process, important substances like amylopectin and arabinoxylans break down into smaller pieces, which affects their properties.
- * The researchers created flexible, see-through films from stale bread that can block light and even help fight off bad stuff, showing that old bread can be used for new purposes!
Article Synopsis
- Tracheal stenosis is a serious complication that can greatly affect a person's quality of life, and the COVID-19 pandemic has increased its occurrence due to more people needing long-term intubation or tracheostomy for severe cases.
- A study in Lombardy, Italy, observed 281 patients who had prolonged intubation or tracheostomy, finding that 8.5% developed tracheal stenosis after an average of 112 days.
- The research indicated that having a tracheostomy and consuming alcohol raised the likelihood of developing stenosis significantly, highlighting the need for monitoring patients post-intubation for at least 200 days.
Introduction: The LIPI, based on pretreatment derived neutrophils/[leukocytes-neutrophils] ratio (dNLR) and LDH, is associated with immune checkpoint inhibitors (ICI) outcomes in advanced non-small-cell lung cancer (NSCLC). We aimed to assess baseline LIPI correlation with durvalumab consolidation outcomes in the locally advanced setting.
Material And Methods: Multicentre retrospective study (330 patients) with stage III unresectable NSCLC treated with durvalumab after chemo-radiotherapy between April 2015 and December 2020; 65 patients treated with chemo-radiotherapy only.