Publications by authors named "M Speletas"
The emergence of SARS-CoV-2 variants of concern (VOCs) during the COVID-19 pandemic necessitates investigation into their clinical differentiation and outcomes. This study aimed to examine these differences among VOCs, considering multiple related factors. An observational cohort study was conducted on patients diagnosed with SARS-CoV-2 infection via nasopharyngeal/oropharyngeal swab who visited the emergency department of a public Greek hospital between October 2020 and July 2022 during different VOC circulation in the region.
View Article and Find Full Text PDFBackground: Biologic agents used in patients with inflammatory bowel diseases (IBD) may influence the pathophysiology of coexistent metabolic-dysfunction associated steatotic liver disease (MASLD). This study primarily aimed to evaluate the six-month effect of infliximab or vedolizumab vs. no biologics on presumed hepatic steatosis in patients with IBD.
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- Natural antibodies (NAbs) are essential for immune defense and regulation, playing a role in preventing autoimmunity and maintaining immune balance, particularly relevant in conditions like Common Variable Immunodeficiency (CVID).
- This study analyzed NAb levels in 56 CVID patients and healthy controls, revealing that IgM NAb levels were significantly lower in IgRT-treated patients compared to untreated patients and controls, with treatment not fully restoring these levels.
- The findings suggest a link between low NAb levels and recurrent infections, while patients with enteropathy or autoimmune diseases showed higher IgM NAb levels, indicating that NAb levels may help monitor disease progression in CVID.
A Nationwide Study of the Delayed Diagnosis and the Clinical Manifestations of Predominantly Antibody Deficiencies and -Mediated Immune Dysregulation Syndrome in Greece.
Medicina (Kaunas)
May 2024
Article Synopsis
- Predominantly antibody deficiencies (PAD) are the most common type of immune problems in people, but it's not well-known how many people have them in Greece.
- A study was done on 153 patients to learn more about these deficiencies, and they found different types of PAD among the patients.
- The study showed that it often took a long time (about 9 years) for people to be diagnosed with PAD after they first noticed symptoms, and many of the patients had more serious health issues like infections and even cancer.
Patients with predominantly antibody deficiencies (PADs) display hypogammaglobulinemia with a high prevalence of infections, along with autoimmune manifestations, benign and malignant lymphoproliferation and granulomatous disease. It is noteworthy that PAD patients, even those with defects in the same causative genes, display a variable clinical phenotype, suggesting that additional genetic polymorphisms, located in either immune-related or non-immune-related genes, may affect their clinical and laboratory phenotype. In this context, we analyzed 80 PAD patients, including 70 with common variable immunodeficiency (CVID) for defects, in order to investigate the possible contribution to PAD clinical phenotype.
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