Publications by authors named "M Soutto"
Helicobacter pylori (H. pylori) infection is the main risk factor for gastric cancer. The SRY-Box Transcription Factor 9 (SOX9) serves as a marker of stomach stem cells.
View Article and Find Full Text PDFHelicobacter pylori (H. pylori) is the leading risk factor for gastric carcinogenesis. Fibroblast growth factor receptor 4 (FGFR4) is a member of transmembrane tyrosine kinase receptors that are activated in cancer.
View Article and Find Full Text PDFObjective: Chronic gastro-oesophageal reflux disease, where acidic bile salts (ABS) reflux into the oesophagus, is the leading risk factor for oesophageal adenocarcinoma (EAC). We investigated the role of ABS in promoting epithelial-mesenchymal transition (EMT) in EAC.
Design: RNA sequencing data and public databases were analysed for the EMT pathway enrichment and patients' relapse-free survival.
Article Synopsis
- - Esophageal adenocarcinoma (EAC) has a low 5-year survival rate of 20%, and smoking significantly contributes to its development and drug resistance, with WEE1 protein being overexpressed in EAC tissues.
- - Research shows that smoking increases WEE1 expression in EAC through the downregulation of miR-195-5p, which plays a role in cell cycle regulation and drug resistance.
- - Targeting WEE1 with specific inhibitors, like MK-1775, in combination with chemotherapy (docetaxel), has been found to improve survival in EAC models, highlighting a potential new approach to overcoming treatment resistance in this aggressive cancer.