Publications by authors named "M Soulsby"
Article Synopsis
- Noonan syndrome (NS) is an autosomal dominant disorder linked to mutations in the PTPN11 gene, leading to symptoms such as congenital heart disease, short stature, and distinct facial features.
- Interestingly, patients with LEOPARD syndrome (LS) have inactivating mutations in the same gene but display similar symptoms, highlighting the complexity of Shp2 signaling.
- The study identifies "protein zero-related" (PZR) as a key protein involved in NS and LS, with its abnormal phosphorylation promoting symptoms by enhancing Shp2 activity and affecting cell migration during zebrafish gastrulation.
The aim of this study was to compare physiological effects of hindlimb suspension (HLS) in tail- and pelvic-HLS rat models to determine if severe stretch in the tail-HLS rats lumbosacral skeleton may contribute to the changes traditionally attributed to simulated microgravity and musculoskeletal disuse in the tail-HLS model. Adult male Sprague-Dawley rats divided into suspended and control-nonsuspended groups were subjected to two separate methods of suspension and maintained with regular food and water for 2 weeks. Body weights, food and water consumption, soleus muscle weight, tibial bone mineral density, random plasma insulin, and hindlimb pain on pressure threshold (PPT) were measured.
View Article and Find Full Text PDFObjective: To assess the efficacy and tolerability of pregabalin for the treatment of central neuropathic pain after spinal cord injury (SCI).
Methods: Patients with chronic, below-level, neuropathic pain due to SCI were randomized to receive 150 to 600 mg/d pregabalin (n = 108) or matching placebo (n = 112) for 17 weeks. Pain was classified in relation to the neurologic level of injury, defined as the most caudal spinal cord segment with normal sensory and motor function, as above, at, or below level.
Introduction: Physiologic alterations caused by oxidative stress can be assessed by measuring tissue malondialdehyde (MDA) levels, a biomarker for oxidative stress. The goal of this study is to determine the consequences of a twenty percent caloric restriction on the increased oxidative stress documented in tissues from rats exposed to simulated microgravity.
Materials/methods: Three groups of male SD rats (N=6 in each group) were used: Group 1, control; Group 2, food restricted (20% less food than control); and Group 3, food restricted with HLS.