Publications by authors named "M Sorosina"
Background: Inter-individual differences in treatment response are marked in multiple sclerosis (MS). This is true for Natalizumab (NTZ), to which a subset of patients displays sub-optimal treatment response. We conducted a multi-centric genome-wide association study (GWAS), with additional pathway and network analysis to identify genetic predictors of response to NTZ.
View Article and Find Full Text PDFMultiple Sclerosis (MS) is a heterogeneous inflammatory and neurodegenerative disease with an unpredictable course towards progressive disability. Treating progressive MS is challenging due to limited insights into the underlying mechanisms. We examined the molecular changes associated with primary progressive MS (PPMS) using a cross-tissue (blood and post-mortem brain) and multilayered data (genetic, epigenetic, transcriptomic) from independent cohorts.
View Article and Find Full Text PDFVitamin D affects the risk of disease activity in multiple sclerosis.
J Neurol Neurosurg Psychiatry
January 2025
Background: Vitamin D (VitD) affects the risk of multiple sclerosis (MS), but the impact on disease activity is controversial. We assessed whether VitD is associated with the No-Evidence of Disease Activity-3 (NEDA-3) status at 2 years from disease-modifying treatment (DMT) start, and whether this association is causal or the result of confounding factors. Furthermore, we explored if a genetic predisposition to higher VitD levels affects the risk of disease activity.
View Article and Find Full Text PDFArticle Synopsis
- Multiple sclerosis (MS) is a diverse condition with varying symptoms and treatment responses, prompting a study on its genetic causes related to disease activity over time.
- Researchers analyzed genetic data from two groups of relapsing-remitting MS patients, examining their genomes and specific gene interactions in brain and lymphocyte tissues to identify key genetic variants and pathways involved in MS.
- The study found 23 genetic variants and 223 associated genes, with significant genes such as PON2 and ILRUN linked to oxidative stress and immune modulation, revealing shared and tissue-specific mechanisms driving MS disease activity.
Article Synopsis
- - This study investigates how DNA methylation, influenced by both genetic and environmental factors, affects disease activity in multiple sclerosis (MS) patients.
- - Researchers analyzed the methylomes of 249 untreated relapsing-remitting MS patients and found four differentially methylated regions correlating with varying disease activity over two years.
- - The findings revealed a significant relationship between specific genetic variants related to the anti-Mullerian hormone and disease activity risk, highlighting a new pathway for understanding MS and the role of sex hormones in its progression.