Publications by authors named "M Sorin"
Enteroviruses are a vast genus of positive-sense RNA viruses that cause diseases ranging from common cold to poliomyelitis and viral myocarditis. They encode a membrane-bound AAA+ ATPase, 2C, that has been suggested to serve several roles in virus replication, e.g.
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- Guidelines suggest using gentamicin alongside other treatments for Enterococcus faecalis infective endocarditis (EFIE) despite potential toxicity; this study aimed to evaluate the safety and effectiveness of gentamicin compared to ceftriaxone.* -
- A systematic review and meta-analysis were conducted, analyzing 10 observational studies, which revealed that gentamicin had similar mortality and treatment failure rates to ceftriaxone but caused significantly more treatment discontinuations due to toxicity.* -
- The findings indicate that ceftriaxone is likely as effective as gentamicin and less toxic, suggesting it may be a preferable option for EFIE treatment until more definitive randomized studies are available.*
Article Synopsis
- Somatic copy number alterations (SCNAs), especially arm-level SCNAs, are linked to cancer growth and resistance to treatment, but their role in triple-negative breast cancer (TNBC) is not well understood.
- In this study, researchers found that certain arm-level SCNAs, like gains at 21q and 7p, are connected to poorer survival rates in TNBC patients, with the gene RIPK4 on 21q being particularly significant.
- Targeting RIPK4 in experiments showed promise, as it reduced tumor growth and improved survival by enhancing immune cell infiltration, suggesting RIPK4 could be a key factor in TNBC progression and its ability to spread.
Background: Pneumocystis jirovecii pneumonia (PCP) is a common opportunistic infection among people living with HIV (PWH), particularly among new and untreated cases. Several regimens are available for the prophylaxis of PCP, including trimethoprim-sulfamethoxazole (TMP-SMX), dapsone-based regimens (DBRs), aerosolized pentamidine (AP), and atovaquone.
Objectives: To compare the efficacy and safety of PCP prophylaxis regimens in PWH by network meta-analysis.