Publications by authors named "M Sone"
Article Synopsis
- Mutations in certain genes are associated with frontotemporal lobar degeneration (FTLD), but whether these mutations lead to gain or loss of function is still debated.
- Research using Drosophila flies showed that knocking down the TER94 gene, similar to the human gene VCP/p97, resulted in severe health issues like early death and changes in brain structure, which were not restored by a known mutant version of the gene.
- The study implies that the issues caused by TER94 knockdown are due to loss-of-function effects, particularly affecting cell proliferation and leading to the loss of another protein, TBPH, from cell nuclei.
Article Synopsis
- The study aimed to identify prognostic factors from neck dissections in patients with regional recurrent or residual head and neck cancer, focusing on continuous variables related to pathologic lymph nodes.
- Researchers analyzed data from 184 patients with head and neck squamous cell carcinomas, evaluating lymph node density (LND) and log odds of positive lymph nodes (LODDS) to estimate survival outcomes.
- Findings revealed that higher LND (≥ 0.14) is significantly associated with poorer survival outcomes, indicating it as a negative prognostic factor after salvage neck dissection.
Objective: Whether metal stents (MS) or plastic stents (PS) yield better outcomes for malignant biliary obstruction in endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) is controversial. We aimed to compare outcomes of initial EUS-HGS performed with MS or PS.
Methods: In this single-center retrospective study, we included patients (MS/PS groups: n = 151/72) with unresectable malignant biliary obstruction and performed multivariable analysis.
Purpose: To evaluate the risk factors of non-diagnostic results based on cause of error in liver tumor biopsy.
Materials And Methods: This single-institution, retrospective study included 843 patients [445 men, 398 women; median age, 67 years] who underwent a total of 938 liver tumor biopsies between April 2018 and September 2022. An 18-G cutting biopsy needle with a 17-G introducer needle was used.