Defining the subcellular distribution of all human proteins and their remodeling across cellular states remains a central goal in cell biology. Here, we present a high-resolution strategy to map subcellular organization using organelle immunocapture coupled to mass spectrometry. We apply this workflow to a cell-wide collection of membranous and membraneless compartments.
View Article and Find Full Text PDFHigher prevalence of inappropriate medication use among cancer patients increases risk of drug-related problems(DRP) like drug-drug interactions, ADR, and non-adherence. Potentially inappropriate medication (PIM) and Potential Prescription Omission (PPO) were identified using Screening Tool of Older Person's Prescriptions (STOPP) and Screening Tool to Alert Doctors to the Right Treatment (START) criteria. The study objective was to optimize prescriptions for the elderly by analyzing the impact of medication review.
View Article and Find Full Text PDFInfections with Gram-positive soil-dwelling bacterium are sporadic. Rarely, do patients with indwelling medical devices or those who suffer from immunosuppression get infected by this pathogen. However, based on routine clinical and laboratory procedures, it is hard to distinguish between the meningitis caused by and that from other bacteria.
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