Inflamed and non-inflamed classes of HCC: a revised immunogenomic classification.

Objective: We previously reported a characterisation of the hepatocellular carcinoma (HCC) immune contexture and described an immune-specific class. We now aim to further delineate the immunogenomic classification of HCC to incorporate features that explain responses/resistance to immunotherapy.

Design: We performed RNA and whole-exome sequencing, T-cell receptor (TCR)-sequencing, multiplex immunofluorescence and immunohistochemistry in a novel cohort of 240 HCC patients and validated our results in other cohorts comprising 660 patients.

Parametric techniques for characterizing myocardial tissue by magnetic resonance imaging (part 1): T1 mapping.

The development of myocardial fibrosis is a common process in the appearance of ventricular dysfunction in many heart diseases. Magnetic resonance imaging makes it possible to accurately evaluate the structure and function of the heart, and its role in the macroscopic characterization of myocardial fibrosis by late enhancement techniques has been widely validated clinically. Recent studies have demonstrated that T1-mapping techniques can quantify diffuse myocardial fibrosis and the expansion of the myocardial extracellular space in absolute terms.

Parametric methods for characterizing myocardial tissue by magnetic resonance imaging (part 2): T2 mapping.

Cardiac magnetic resonance imaging is considered the reference technique for characterizing myocardial tissue; for example, T2-weighted sequences make it possible to evaluate areas of edema or myocardial inflammation. However, traditional sequences have many limitations and provide only qualitative information. Moreover, traditional sequences depend on the reference to remote myocardium or skeletal muscle, which limits their ability to detect and quantify diffuse myocardial damage.

[Bladder metastasis of malignant melanoma: report of a case].

Objectives: To report one case of malignant melanoma metastasis into the urinary tract, diagnosed after excision of the primary lesion.

Methods: Case of a 75 year old male with history of malignant melanoma in the scapular region excised 7 years before who presents with lower urinary tract symptoms (LUTS), hematuria and a hypogastric mass, 12 cm in diameter, located superficially and anterior to the bladder. He underwent partial cystectomy for excision of the mass, prostate adenomectomy and lithiasis extraction.