Publications by authors named "M Sokabe"
From stress fiber to focal adhesion: a role of actin crosslinkers in force transmission.
Front Cell Dev Biol
August 2024
The contractile apparatus, stress fiber (SF), is connected to the cell adhesion machinery, focal adhesion (FA), at the termini of SF. The SF-FA complex is essential for various mechanical activities of cells, including cell adhesion to the extracellular matrix (ECM), ECM rigidity sensing, and cell migration. This mini-review highlights the importance of SF mechanics in these cellular activities.
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- - Stroke is a top cause of death and disability globally, and while tPA is the best current treatment, it only works within 4.5 hours after symptoms begin.
- - Research shows that nestorone, a progesterone receptor agonist, offers neuroprotection when given up to 18 hours post-stroke in adult and aged male rats, improving behavior and reducing damage compared to a control group.
- - Nestorone also lowers inflammation markers in the brain post-stroke, indicating its potential as a more effective treatment due to its longer therapeutic window compared to tPA.
Translation is regulated mainly in the initiation step, and its dysregulation is implicated in many human diseases. Several proteins have been found to regulate translational initiation, including Pdcd4 (programmed cell death gene 4). Pdcd4 is a tumor suppressor protein that prevents cell growth, invasion, and metastasis.
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