Publications by authors named "M Sobaniec-Lotowska"
Ultrastructural Analysis of the Large Neuronal Perikarya in an Injured Dentate Nucleus Using an Experimental Model of Hyperthermia-Induced Convulsions: The First Qualitative and Quantitative Study.
J Clin Med
September 2024
Article Synopsis
- Febrile seizures are a common type of convulsion in kids, and this study aims to understand how they happen by looking closely at brain cells in rats.
- The researchers heated the rats to make them have seizures, then used special microscopes to see what happened to the brain cells.
- They found that the brain cells showed serious damage when the rats were heated, which could help scientists find ways to prevent seizures in children in the future.
Unlabelled: The aim of the study was the pioneering retrospective ultrastructural evaluation of respective forms of hepatic stellate cells (HSCs) and analysis of their crosstalk with other adjacent nonparenchymal cells (NPCs), especially Kupffer cells/macrophages (KCs/MPs), in pediatric autoimmune hepatitis (AIH).
Methods: Ultrastructural assessment of the HSC population and NPCs was performed in transmission electron microscopy (TEM) using pretreatment liver biopsies from 25 children (8 boys and 17 girls) aged 4-17 with clinic-pathologically diagnosed untreated AIH.
Results: Submicroscopic evaluation allowed easy identification of numerous HSCs in the form of transitory cells, i.
Article Synopsis
- The study explored the neuroprotective effects of topiramate (TPM), an antiepileptic drug, on synaptic damage in the temporal lobe caused by hyperthermia-induced seizures in young male rats.
- It found that administering TPM before the seizure event reduced synaptic damage and improved the structure of synapses, especially near healthy blood vessels.
- However, giving TPM after the seizures did not prevent any synaptic injury, highlighting the importance of timing in its protective effects.
Considering that the heterogenic population of a hepatic progenitor cell line (HPCL) can play a vital role in autoimmune hepatitis (AIH), we decided to conduct pioneering retrospective evaluation of these cells in pediatric AIH by means of transmission electron microscopy (TEM). The aim of the study was to assess the ultrastructure of the HPCL in children with untreated AIH. Ultrastructural analysis of the HPCL population, preceded by immunohistochemical staining for cytokeratin 7 (CK7), was performed using pretreatment liver biopsies from 23 children with clinicopathologically diagnosed AIH.
View Article and Find Full Text PDFBackground: An increase in the incidence of eosinophilic esophagitis worldwide is being observed in children. The aim of the study was to analyze the incidence, clinical manifestations, biochemical markers and endoscopic features of children with eosinophilic esophagitis in comparison to patients with non-eosinophilic esophagitis.
Methods: This single-center retrospective study included newly diagnosed children with eosinophilic (EoE) and non-eosinophilic (non-EoE) esophagitis based on endoscopic and histopathological results between January 2013 and December 2018.