Publications by authors named "M Snowden"
Article Synopsis
- - Mechanistically targeted behavioral interventions, like problem-solving therapy, can improve depression outcomes by modifying neural circuits, which is especially essential for vulnerable groups with comorbid conditions such as obesity.
- - The study used functional magnetic resonance imaging to track cognitive control circuit activity in participants over 24 months, revealing that reduced activity in this circuit linked to better problem-solving skills and lower depression symptoms.
- - Changes in cognitive control circuit activity at 2 months were effective predictors for later improvements in problem-solving and depression, indicating a need for refining these circuit-based models for better clinical use.
Streptococcus pyogenes Cas9 (SpCas9) and derived enzymes are widely used as genome editors, but their promiscuous nuclease activity often induces undesired mutations and chromosomal rearrangements. Several strategies for mapping off-target effects have emerged, but they suffer from limited sensitivity. To increase the detection sensitivity, we develop an off-target assessment workflow that uses Duplex Sequencing.
View Article and Find Full Text PDFDepression remains a major public health issue for older adults, increasing risk of costly health services utilization. While home-based collaborative care models (CCM) like PEARLS have been shown to effectively treat depression in low-income older adults living with multiple chronic conditions, their economic impact is unclear. We conducted a quasi-experimental study to estimate PEARLS effect on health service utilization among low-income older adults.
View Article and Find Full Text PDFBackground: Embedding evidenced-based programs (EBPs) like PEARLS outside clinical settings can help reduce inequities in access to depression care. Trusted community-based organizations (CBOs) reach older adults who are underserved; however, PEARLS adoption has been limited. Implementation science has tried to close this know-do gap, however a more intentional focus on equity is needed to engage CBOs.
View Article and Find Full Text PDFArticle Synopsis
- Scientists studied a lot of people's genes to see if certain gene changes were linked to diabetes.
- They found out that some people with these gene changes were less likely to get diabetes, even if they were overweight.
- They also saw that a specific gene change in Finnish people was connected to having lower chances of both types of diabetes and didn't cause any bad health effects.